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  2. Role and association of Hsp90, Her2, p53 and Ki-67 in Gastric and Colorectal Neopalasms in Indian context

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Role and association of Hsp90, Her2, p53 and Ki-67 in Gastric and Colorectal Neopalasms in Indian context

    Authors

    • Dr Sunethri Padma 1
    • Dr Rahul Dev Singh Rathore 2
    • Dr Shravan Kumar Odapally 3
    • Dr Shravan Kumar Parika 4
    • Dr Uday Kumar Putcha 5

    1 Associate Professor of Pathology, Gandhi medical college, Hyderabad, Telangana, India

    2 Consultant Pathologist, Yashoda Hospitals, Hyderabad, Telangana, India

    3 Dean and Professor of Pathology, RVM Medical College, Telangana, India

    4 Professor and Head of Gastroenterology, Gandhi Medical College Hyderabad, Telangana, India

    5 Senior Scientist G, National Institute of Nutrition, Hyderabad, India

,

Document Type : Research Article

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Abstract

Introduction: Gastrointestinal malignancies are on raise and there is a need for predictive and prognostic markers to study the tumor behavior. In the present study we have evaluated four most important markers in these tumors in Indian population so that drugs targeting these proteins can be included in the therapeutic regimes. We also compared the expressions with the grade and stage of the tumors. Materials and methods: The present study is an observational cross-section study. We have included neoplasms of Stomach, Colon and Rectum, 30 benign and 30 malignant neoplasms from each organ. Results: HSP90 expression was associated with the grade and stage of all tumors except grade of colonic tumors. HER2 was associated with grade and stage of all tumors except stage of stomach & rectum and grade of carcinoma colon. Ki-67 expression was associated with grade and stage of all tumors except stage of rectal carcinoma. p53 is associated with grade and stage of all the tumors. Conclusion: Marked geographical variations have been identified in the phenotypic characters of the tumors. An understanding of the pattern of expression of prognostic and predictive markers shall be helpful in better analysis of the tumor behavior.

Keywords

  • Gastrointestinal neoplasms
  • HSP90 expression
  • Ki-67 expression
  • p53 expression
  • Her2 expression
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 10
December 2020
Page 2207-2222
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  • Article View: 189
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APA

Padma, D. S., Singh Rathore, D. R. D., Odapally, D. S. K., Parika, D. S. K., & Putcha, D. U. K. (2021). Role and association of Hsp90, Her2, p53 and Ki-67 in Gastric and Colorectal Neopalasms in Indian context. European Journal of Molecular & Clinical Medicine, 7(10), 2207-2222.

MLA

Dr Sunethri Padma; Dr Rahul Dev Singh Rathore; Dr Shravan Kumar Odapally; Dr Shravan Kumar Parika; Dr Uday Kumar Putcha. "Role and association of Hsp90, Her2, p53 and Ki-67 in Gastric and Colorectal Neopalasms in Indian context". European Journal of Molecular & Clinical Medicine, 7, 10, 2021, 2207-2222.

HARVARD

Padma, D. S., Singh Rathore, D. R. D., Odapally, D. S. K., Parika, D. S. K., Putcha, D. U. K. (2021). 'Role and association of Hsp90, Her2, p53 and Ki-67 in Gastric and Colorectal Neopalasms in Indian context', European Journal of Molecular & Clinical Medicine, 7(10), pp. 2207-2222.

VANCOUVER

Padma, D. S., Singh Rathore, D. R. D., Odapally, D. S. K., Parika, D. S. K., Putcha, D. U. K. Role and association of Hsp90, Her2, p53 and Ki-67 in Gastric and Colorectal Neopalasms in Indian context. European Journal of Molecular & Clinical Medicine, 2021; 7(10): 2207-2222.

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