“Clinical Profile And Comparison Of Narrow Versus Broad Spectrum Antibiotic Therapy For Community Acquired Pneumonia In Children Hospitalized At Tertiary Care Centre”
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 8, Pages 4578-4589
AbstractBackground: Pneumonia is the leading cause of morbidity and mortality in under 5 year age children. Objective: To compare the effectiveness of treatment for Community Acquired Pneumonia (CAP) in children with narrow versus broad spectrum antibiotic therapy. Methods: A prospective randomized controlled trial was conducted in Pediatric ward of tertiary care medical college hospital of southern Rajasthan from July 2017 to June 2018. Total 184 children of age group of 2 months to 18 years, admitted with a clinical diagnosis of CAP were enrolled for the study. Results:A total 184 children were enrolled.Maximum no. of cases (93) admitted with CAP were among 2 months to 12 months of age group. All 6 parameters in our study (i.e. total duration of fever, O2requirement, respiratory distress, length of stay, change of antibiotic and readmission) were compared between both the groups suggesting that Ampicillin having similar effect on children hospitalized with CAP when compared with Ceftriaxone.Throat swab culture in children with CAP was positive in 55% of cases. Most common organism grown on throat swab of affected children was Streptococcus pneumoniae (30%) followed by H.influenzae (15%).Conclusion:CAP is a major health problem in children below 5 years. Most common organism for CAP in children is still S.pneumoniae. In our study narrow spectrum antibiotic coverage for CAP was associated with similar outcomes when compared with broad spectrum agent. So we highlights in our study to promote the use of narrow spectrum antibiotics in children hospitalized with CAP.
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