PAMAM DENDRIMER-BASED LULICONAZOLE GEL FORMULATION AND EFFICIENCY EVALUATIONS
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 8, Pages 4881-4894
Abstract
This research is aimed at developing the PAMAM dendrimer mediated transdermal formulation of Luliconazole and explore the potential of PAMAM dendrimer as noval drug delivery to enhance the skin permeation and to avoid the serious toxic effects caused by oral and other topical formulation available.Solubility, Identification and characterization of drug of drug were carried out using various parameters like Organoleptic properties, Solubility Study of Drug, Melting Point, Partition Coefficient (Kp), Fourier Transform Infrared Spectroscopy of Drug and Drug Release Kinetics. Optimized formulation was further assessed by evaluation of gel studies along with accelerated stability study. FTIR spectrum of luliconazole confirms the presence of different groups and matched with the values as reported in official Pharmacopoeia. The melting point determined of luliconazole found to be 150-152 °C. Luliconazole was found to be soluble in methanol, Methanol, DMSO, Di-methyl formamide and Chloroform.In the solubilization studies, the effect of dendrimer concentration, pH of the solution of Luliconazole was investigated. Luliconazole with a pKa of 4.15 exhibits pH dependent solubility.It has been concluded that luliconazole was distributed with the PAMAM dendrimer and that PAMAM dendrimer may be used as a potential medication to enhance skin permeation and avoid severe toxic effects caused by the oral or other existing wording.
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