Toxicological Effects of Paraphenylene-diamine On Skin Of Albino Rats-An In-vivo Study
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 5163-5167
Abstract
Materials and methods: This study was undertaken on 24 albino rats, in the department of anatomy in Govt. Medical College Jammu. These rats were divided into four groups of 6 rats each. Group A, Group B, Group C rats were painted with 1mg/kg body wt, 2mg/kg body wt and 3 mg/kg body wt of paraphenylene-diamine respectively while Group D rats were painted with distilled water after shaving their backs.Results: There were gross and histological changes in the liver and skin of the albino rats by the repeated topical application of paraphenylene-diamine on the albino rats.
Conclusion: Repeated topical application of paraphenylene-diamine results in systemic absorption of the dye and consequent damage of the internal organs.
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