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  2. Volume 7, Issue 11
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Online ISSN: 2515-8260

Volume7, Issue11

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TRIAZOLYL QUINAZOLIN-4-ONE DERIVATIVES AS ANTICANCER AGENTS

    Khairnar N. S. Patil A. V. Noolvi M. N.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 5201-5214

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Abstract

A novel series of triazolylquinazolin-4-one derivatives have been synthesized and characterized by TLC, melting point, FT-IR, 1H NMR and mass spectroscopy data. The synthesized series of title compounds were subjected for docking studies using Schrodinger Glide software, evaluated for their potential to inhibit enzyme EGFR-tyrosine kinase followed by in-vitro anticancer activity by SRB assay method on HeLa, MCF-7, A-549 cell lines. The series of compounds shows anticancer activity probably by inhibiting the enzyme EGFR-tyrosine kinase.
Keywords:
    Anticancer Activity EGFR Molecular docking SRB assay synthesis Tyrosine Kinase triazolylQuinazolin-4-ones
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(2021). SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TRIAZOLYL QUINAZOLIN-4-ONE DERIVATIVES AS ANTICANCER AGENTS. European Journal of Molecular & Clinical Medicine, 7(11), 5201-5214.
Khairnar N. S.; Patil A. V.; Noolvi M. N.. "SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TRIAZOLYL QUINAZOLIN-4-ONE DERIVATIVES AS ANTICANCER AGENTS". European Journal of Molecular & Clinical Medicine, 7, 11, 2021, 5201-5214.
(2021). 'SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TRIAZOLYL QUINAZOLIN-4-ONE DERIVATIVES AS ANTICANCER AGENTS', European Journal of Molecular & Clinical Medicine, 7(11), pp. 5201-5214.
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TRIAZOLYL QUINAZOLIN-4-ONE DERIVATIVES AS ANTICANCER AGENTS. European Journal of Molecular & Clinical Medicine, 2021; 7(11): 5201-5214.
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