Serum level and interleukin 9 genetic polymorphisms In patients with tonsillitis
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 1, Pages 1590-1599
Abstract
The study investigated the relationship between the polymorphism of the IL-9 gene at position -6676 for the variation rs1799962 for tonsillitis among patients in Baquba, which included 31 male samples with an average age of (15.65 ± 1.79) years compared to 5 healthy males with an average age (14.66 ± 3.43) years enrolled in this study the polymorphism of IL9-6676 was data waved by polymerase chain reaction-specific sequence primer (PCR-SSP) assay.As the results of the electrophoresis of the IL- 9 gene at position -6676 showed a comparison genotypes & alleles between tonsillitis patients & controls frequencies of AA genotype & A allele, showed that a significant increase in patients with tonsillitis (45.16% and 72.58% P =1.000 respectively) Compared to the control (70% and 40% P= 0.431 respectively) and associated RR rates were(8.6% and 38.0% respectively.) and And the related EF values were (1.24 and 1.75). In contrast AG genotype & G allele (35.48 vs. 17.74, P =0.357 respectively). Decreased frequency was observed in patients compared to the control (30% and 60% P =0.431) , and the related PF values were (0.37 and 0.57 respectively). The results of the study indicate that IL9-6676 SNP may have a role in the mechanism of etiopathogenic. It was observed that it has a negative and positive role in the samples with tonsillitis in the samples of Iraqi patients
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