Clinic-etiologic profile and factors associated with severity of acute pancreatitis: an observational study
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 8, Pages 5038-5044
AbstractAim: to evaluate the parameters associated with severity of acute pancreatitis.
Material and methods: This Prospective observational study was done in the Department of Surgery, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India for 1 year. Total 100 patients diagnosed as acute pancreatitis on the basis of clinical signs, biochemical markers and radiological signs were included in this study. they were investigated by various blood investigations like haemoglobin, total leukocyte count, differential count, haematocrit, calcium, Blood urea nitrogen (BUN), arterial blood gas analysis, serum electrolytes, Random blood sugar (RBS), liver function tests, Lactate dehydrogenase (LDH), serum amylase, serum lipase, ultrasound abdomen and contrast Computed tomography (CT) for those indicated. The two commonly used scoring systems in our institution were also analysed viz. Ranson’s score and modified Glasgow score.
Results: Out of 100 patients, 76(76%) were males and 24 (24%) were females. Majority cases were seen in between 40 to 50 years 35 (35%). 70 cases were mild acute pancreatitis (70%), 18 cases were moderately severe acute pancreatitis (18%) and 12 cases severe acute pancreatitis (12%). The majority of cases who presented with acute pancreatitis were of alcohol induced type, 67 (67%). Gall stone pancreatitis accounted for 19 (19%) cases. 60 (60%) patients had diabetes mellitus, 42(42%) had hypertension and 48 (48%) had dyslipidemia. Major co-morbidity was diabetes mellitus among the studied population. In our study the 39 cases were having a Body mass index (BMI) of 18.5 to 24.9 (50%) and 8 (8%) were having a BMI of above 30 and 39 (44%) had BMI 18.5 to 19.9. Majority of the cases 70 (70%) who presented were having habit of consuming alcohol. 4 (4%) patients in our study died due to complications of severe acute pancreatitis.
Conclusion: One should not wait for any single scoring system to get scored for effective treatment. A diagnosis of pancreatitis should be made using clinical, laboratory and radiological means and treatment in the form of aggressive crystalloid resuscitation should be started with intensive care monitoring at the earliest.
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