European Journal of Molecular & Clinical Medicine

Abstract

The aim of our study was to study the features of impaired left ventricular diastolic function in patients with chronic heart failure, depending on the clinical course of the disease. A total of 131 patients with CHF of ischemic origin with I, II and III FC CHF (men aged 38-60 years, mean age 54.51 ± 6.89 years) were examined. Patients with FC I were 31 (23.7%) patients, with FC II - 51 (38.9%) and FC III - 49 (37.4%) patients. The structural
and functional state of the myocardium and the process of LV remodeling were assessed by echocardiography with Doppler ultrasonography. EchoCG was performed on the device "MEDISON ACCUVIX V20" (South Korea), using a 3.25 MHz transducer in standard echocardiographic positions, transthoracic method in accordance with the recommendations of the American Society of Echocardiography (ASE). In patients with CHF, diastolic function disorders were identified in 74.8% of cases: grade I (impaired relaxation) was recorded in 38.9% (51 patients), grade II - (pseudonormal) in 21.4% (28), type III (reversible restrictive) - in 14.5% (19) patients. An analysis of the grades of diastolic dysfunction showed the predominance of relaxation disorders in 52% of patients and an increase in the number of patients with restrictive type of diastolic dysfunction with an increase in CHF FC. Thus, in 74.8% of CHF patients, impaired LV diastolic function was observed, characterized by its deterioration with the progression of the disease. At the same time, impaired LV diastolic function was characterized to a greater extent by impaired relaxation, and with the progression of the disease, a restrictive type of LVDD impairment.