Vascular Endothelial Growth Factor-A Plasma Level and-460 VEGF Gene Single Nucleotide Polymorphism Significance in Childhood Acute Lymphoblastic Leukemia in Basrah, Iraq
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 2, Pages 1212-1219
AbstractBackground: Vascular Endothelial Growth Factor –A (VEGF-A) has a vital role in angiogenesis inhematological malignancies including acute lymphoblastic leukemia (ALL).Many singlenucleotide polymorphisms(SNPs) in VEGF gene may affect susceptibility of ALL in children.
Aim of the study: To investigate the frequency of -460 VEGF gene SNP and their impact on plasma level of VEGF-Ain children with ALL.
Material and method: This study included 40 children with ALL and 40 healthy children as controlcarriedout at the Oncology Unit in Basrah Children specialty Hospital from Oct 2019 to March 2020. VEGF-A plasma level evaluated using ELISA assay, PCRteqnique was used to detect the -460 VEGF SNP.
Result:VEGF-Aplasma level in ALLchildren was higherthan control, there is significant difference of -460 VEGFSNP between ALLchildren and healthy control and the impact of gene polymorphism on plasma level of VEGF-A in ALL children was highly significant.
Conclusion: VEGF-A level and gene SNPcould play a central role in ALL pathogenesisand progression.
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