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Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats

    Authors

    • Akmal Ahmed Hassan Diab, MD
    • Khaled Abdelfattah Abulfadle
    • MD; Nourelhuda A. Mohammed
    • MD and Fatma NabilHashim

    Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

,

Document Type : Research Article

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Abstract

Acute kidney injury is a common complication of myocardial infarction (MI) and scarce data were available on the effect of vitamin D3 on heart and kidney functions in MI. In this study, we investigated the potential protective effect of vitamin D3 on cardiorenal functions in isoproterenol-induced MI in rats and the possible mechanisms involved. It was shown that in MI rats, there was a significant increase in serum levels of (creatine kinase myoglobin binding, lactate dehydrogenase, creatinine, malondialdehyde, interlukin-6 and tumor necrosis factor alpha) and urine levels of (total protein and albumin), with a significant decrease in urine creatinine level, creatinine clearance and serum levels of [reduced glutathione and 1, 25 dihydroxy vitamin D] in comparison with
the control rats. On treatment of rats with vitamin D3 prior to induction of MI, thesebchanges were significantly improved in comparison with the MI rats. Histopathologicalband immunohistochemical examinations of heart and kidney in MI rats reflected the deterioration in their structures with presence of marked apoptosis which were ameliorated on treatment of rats with vitamin D3 prior to induction of MI. In conclusion, vitamin D has a protective effect on heart and kidney functions in the rat model of myocardial infarction and this beneficial effect could be related to its anti-inflammatory, antioxidant and anti-apoptoticactions.

Keywords

  • Myocardial Infarction
  • vitamin D3
  • Acute Kidney Injury
  • Isoproterenol
  • apoptosis
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European Journal of Molecular & Clinical Medicine
Volume 8, Issue 2
January 2021
Page 1341-1357
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  • Article View: 311
  • PDF Download: 374

APA

MD, A. A. H. D., Abulfadle, K. A., Mohammed, M. N. A., & NabilHashim, M. A. F. (2021). Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats. European Journal of Molecular & Clinical Medicine, 8(2), 1341-1357.

MLA

Akmal Ahmed Hassan Diab, MD; Khaled Abdelfattah Abulfadle; MD; Nourelhuda A. Mohammed; MD and Fatma NabilHashim. "Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats". European Journal of Molecular & Clinical Medicine, 8, 2, 2021, 1341-1357.

HARVARD

MD, A. A. H. D., Abulfadle, K. A., Mohammed, M. N. A., NabilHashim, M. A. F. (2021). 'Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats', European Journal of Molecular & Clinical Medicine, 8(2), pp. 1341-1357.

VANCOUVER

MD, A. A. H. D., Abulfadle, K. A., Mohammed, M. N. A., NabilHashim, M. A. F. Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats. European Journal of Molecular & Clinical Medicine, 2021; 8(2): 1341-1357.

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