Effect of chronic exposure of wood dust on serum malondialdehyde, C-reactive protein in sawmill workers and their correlation with pulmonary function parameters.
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 2, Pages 1708-1717
Abstract
Background: Exposure to wood dust reduces the pulmonary function and it may cause inflammation and oxidative damage. A correlation of the biochemical parameter to the spirometric values of lung function parameters may be useful in selecting an alternative test parameter to assess lung function in conditions where performing spirometry is difficult.Objectives: Assessment of biomarker of oxidative stress, malondialdehyde (MDA), and inflammatory marker, c-reactive protein (CRP) along with pulmonary function test parameters, forced expiratory volume at first second (FEV1), forced vital capacity (FVC) and their ratio (FEV1/FVC) in sawmill workers and comparing with non sawmill workers.Correlation of biomarkers with pulmonary function test results.
Methods: Spirometric measurements were taken by advising the subjects to breathe through the instrument. Serum MDA and CRP were estimated in the collected blood using standard procedures.
Results: Significantly elevatedSerum MDA and CRP and lower lung function parameters, FEV1, FVC and FEV1/FVC were observed in sawmill workers compared to non sawmill workers. A significant positive correlation was observed between FVC and MDA with CRP. FEV1/FVC showed a significant negative correlation with MDA.
Conclusion: Serum MDA and CRP were high in sawmill workers. Serum MDA may be used as an indicator of reduced pulmonary function in case of difficulty in performing spirometry
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