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  2. Volume 7, Issue 11
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Online ISSN: 2515-8260

Volume7, Issue11

Differential Recruitment of Monocytes Subsets in Chronic Hepatitis C Patients

    Nora E. El-Bassiouni Mona E. Madkour Raafat I. Atta Mohamed D. El Talkawy Azza M. El Amir Alyaa A. Farid Noha A. Amin

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 6071-6082

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Abstract

Background: Collagen producing myofibroblast activation of is critical for pathogenesis of liver fibrosis. Aim of the work: To study the expansion of peripheral monocyte subsets in HCV patients. Subjects and Methods: Sixty HCV patients were classified according to METAVIR score into 4 stages of liver fibrosis, 15 age and sex-matched controls were include. Flowcytometric analysis of peripheral blood monocytes subsets and CCR2+ve cells was
carried out using monoclonal anti-CD45, anti-CD14, anti-CD16, anti-collagen type I and anti-CCR2antibodies. MCP-1 and SAP levels were assessed using ELISA. Results and Conclusions: A down regulation (p< 0.01) in the classical monocytes subset and an up regulation (p< 0.01) in both the non-classical monocytes and monocytes
producing collagen subsets were notice in HCV patients compared to controls. A marked increase (p< 0.01) in the levels of MCP-1 and monocytes expressing CCR2 with a significant decrease (p< 0.01) in SAP levels, which paralleled the progression of liver fibrosis, were also noticed. MCP-1 and CCR2 may trigger monocytes recruitment to the injured liver promoting the development of collagen type I producing monocytes. The shift
of classical monocyte subset towards the non-classical and collagen producing subsets may be present a predictive non-invasive biomarkers for progress of liver fibrosis.
Keywords:
    HCV liver fibrosis monocytes CCR2 MCP-1 SAP
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(2021). Differential Recruitment of Monocytes Subsets in Chronic Hepatitis C Patients. European Journal of Molecular & Clinical Medicine, 7(11), 6071-6082.
Nora E. El-Bassiouni; Mona E. Madkour; Raafat I. Atta; Mohamed D. El Talkawy; Azza M. El Amir; Alyaa A. Farid; Noha A. Amin. "Differential Recruitment of Monocytes Subsets in Chronic Hepatitis C Patients". European Journal of Molecular & Clinical Medicine, 7, 11, 2021, 6071-6082.
(2021). 'Differential Recruitment of Monocytes Subsets in Chronic Hepatitis C Patients', European Journal of Molecular & Clinical Medicine, 7(11), pp. 6071-6082.
Differential Recruitment of Monocytes Subsets in Chronic Hepatitis C Patients. European Journal of Molecular & Clinical Medicine, 2021; 7(11): 6071-6082.
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