Determining the association between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus: an observational study
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 10, Pages 3504-3510
AbstractBackground: Patients with type 2 diabetes have an increased prevalence of lipid abnormalities, contributing to their high risk of cardiovascular diseases (CVD). This study is an attempt to evaluate the diagnostic value of Glycated haemoglobin (HbA1c) in predicting diabetic dyslipidemia.
Aim: The aim of this study to determine the relation between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus.
Material and methods: This prospective observational study was carried out in the Department of General Medicine, Netaji Subhas Medical College and Hospital, Amhara, Bihta, Patna, Bihar, India for 1 year. The patients above 30 years with fasting venous blood glucose value equal or more than 100 mg/dl and postprandial glucose >140 mg/dl were include in this study. FBS and PPBS, CRP (immunoturbidimetric method), and HbA1C (ion exchange chromatography using HPLC) lipid profile samples were drawn at entry and at subsequent follow-up with a minimum gap of 3-6 months.
Results: There was no significant difference between gender, age and BMI (p>0.05). FBS and HbA1C were directly correlated. PPBS showed a direct correlation with both HbA1C and CRP in this study. There was a significant positive correlation between CRP and total cholesterol (p<0.05). There was no significant correlation between CRP and LDL cholesterol (p>0.05). There was a negative correlation between HDL cholesterol and CRP. There was significant positive correlation between CRP and triglyceride levels (p<0.05). There was significant correlation between CRP and HbA1C (p<0.05).
Conclusion: Timely screening and early detection of the increased hs-CRP in the first-degree relatives of T2DM subjects may help clinicians enable to intervene early in the course of disease and to prevent further complications and outcomes. Therefore, primary prevention by target screening among high-risk individuals to prevent transition to overt T2DM by therapeutic lifestyle changes is a feasible and attractive alternative to reduce diabetes-related morbidity and mortality.
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