Morphogenetic evaluation of the prostate gland in human foetuses: an observational study
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 9, Pages 3281-3286
AbstractAim: evaluate the morphogenesis of the prostate gland in human foetuses.
Materials and methods: The present study was the conducted in Department of Anatomy. Total 100 discarded placentae were collected at random from deliveries (both vaginal and caesarian) conducted Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India, for 1 year. Total 100 foetuses of different gestational ages ranging from 14 weeks (80 mm) to 40 weeks (450 mm), products of terminated pregnancies under MTP Act of India, 1971 and stillbirths were collected from the Department of anatomy. Only those foetuses which were free from any gross anatomical abnormality were selected for the present study. The age of the foetuses were assessed from the obstetrical history, crown rump length (CRL) and gross features before fixation. The foetuses were preserved in 10% formalin for 12 to 15 days. The specimen were categorised into different age groups for study.
Results: The first time of appearance of the prostate gland to the naked eye till its definitive adult shape (at term) is studied in detail. GROUP I: 14 Weeks: In the earliest specimen of this series (14weeks; CRL-7.7 cm), the developing prostate is seen as jelly like, slight fusiform bulge along the upper half of the developing urethra i.e. in the lower part of the urogenital sinus . GROUP II: 14 -18 Weeks: Prostate is more prominent and better defined than the previous age group and has gained in size, but still its length is more than its transverse measurement. GROUP III: 18 -22 Weeks: At subsequent age groups i.e. at 20 weeks it increases in size. Posterolaterally, the prostate is more prominent and the posterior surface looks flat. GROUP IV: 22-26 Weeks: At this stage, there is overall increase in size in all dimensions, thus gain in anteroposterior and transverse measurements resulting as lateral convexities. the transverse dimension is more than the vertical and anteroposterior dimensions. GROUP V: 26-30 Weeks: The prostate shows more increase in its transverse dimension. The posterior aspect seems to support the lower part of the urinary bladder in a funnel shaped way. Thus at around 30 weeks, it has a stunted pear shape appearance whose anterior portion has developed into a firm mass. GROUP VI: 30-34 weeks: With further increase in size in all dimensions, the shape of the prostate assumes as that of an adult. GROUP VII: 34-40 weeks: With further growth in this age group, there is overall increase in all dimensions. The posterior surface is flattened and the upper and lateral surface is occupied by the two lateral lobes.
Conclusion: Increase in vertical and transverse dimensions, assumption of adult shape were noted as the age changes and at term, it has all the three components of the adult tissues although it is not as mature as in adult. This signifies that the growth of the prostate continues postnatally.
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