European Journal of Molecular & Clinical Medicine

Abstract

Desmoplastic ameloblastoma (DA) a rare type of ameloblastoma, arises from the rests of dental lamina, developing enamel organ, epithelial lining of odontogenic cyst or from the basal cells of the oral mucosa. Clinically, DA develops as a slow growing, painless, bony hard swelling resulting in facial asymmetry. Histologically, it represents stromal collagenization or desmoplasia with small nests and strands of odontogenic epithelium. But the true biologic profile of DA is not well understood as they mimic fibro-osseous lesions clinico-radiographically. As DA is a rare entity,we aim to discuss three case reports of DA from a single institution which deserves pre-eminence owing to its distinct site, radiological and histological features, local aggressiveness and high chance of false clinical appearance. Desmoplasia is an inductive phenomenon occurring in the mesenchymal tissue of the head and neck region. The pathologist and the clinician should be aware of the concepts and the association with malignant transformation and spread of the lesion in order to deliver appropriate treatment.