ANTIMICROBIAL ACTIVITY OF NISINPRODUCED BY LACTOCOCOCCUSLACTIS SUBSP. LACTIS AGAINST MULTI DRUG-RESISTANT ORAL PATHOGENS.
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 6714-6722
Abstract
The development and spread of pathogenic bacteria that are resistant to the existing catalog of antibiotics is a major public health threat. Biofilms are complex, sessile communities of bacteria embedded in an organic polymer matrix which serve to further enhance antimicrobial resistance. Consequently, novel compounds and innovative methods are urgently required to arrest the proliferation of drug-resistant infections. Nisin is a lantibiotic widely used for the preservation of food and beverages.Recently, investigators have,reported,that,nisin,may,have,clinical,applications,fortreatingbacterialinfections.TheaimofthisstudywastoinvestigatetheeffectsofNisinon multi drug resistant oral bacteria, isolated from human oral cavities.Chlorhexidine resistant Streptococcus mutans, penicillin resistant Streptococcus sanguinis and Streptococcus gordonii, tetracycline resistant Streptococcus mitis,,metronidazole,resistantLactobacillus,acidophilus,and,Actinomycesisraeliiwere,isolated,from,supragingigival,biofilms.Theminimuminhibitoryconcentrationsandminimumbactericidalconcentrationsoftaxonomicallydistinctoralbacteriaweredeterminedusing,agarandbrothdilutionmethods.Nisininhibitedplanktonicgrowthoforalbacteriaatlowconcentrations(2.5–50μg/ml).Accordingly, it has been suggested that antimicrobial peptides could be used as novel,natural,inhibitors,that,can,be,used,in,formulations,with,synergistically,acting,antibiotic.Thisworkhighlightsthepotentialtherapeuticvalueoffoodgradenisintoinhibitthegrowthoforalbacteriaandthedevelopmentofbiofimsrelevanttooraldiseases.
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