European Journal of Molecular & Clinical Medicine

Abstract

Background: Tendons are dense connective tissues composed primarily of a highly
organized type I collagen extracellular matrix (ECM). Which enables a tendon to perform its
mechanical function of force transfer. Platelet rich plasma (PRP) serves as a growth factor
agonist and has both mitogenic and chemotactic properties.
Aim: investigation the effect of PRP in tendon healing in rats, and evaluation the rate of
possible complications.
Materials and Methods: The study included (35) rats, (5) rats only used as donors for PRP,
while (30) rats separated as PRP group:(1); injection, group (2); spray, group (3); mixed.
The left leg in all rats (control group) receives nothing, while the right leg receives PRP as
separated groups. Each rat was kept in a separated cage and checked on until the end of the
follow up period (15-30) day. After (15) and (30) days post-treatment, (5) rats of each group
were sacrificed, and their Achilles tendons were extracted and examined histopathologically.
Stained sections examined for the number of the inflammatory cells / HPF,
the ratio between collagen 1 and collagen 3 and the arrangement of the collagen fibers