Doxylamine, a histamine H1 antagonist, has potent sedative properties. It has also antiemetic, hypnotic, and allergy properties. An antihistaminic that is commonly used to treat and prevent nausea and vomiting is doxylamine succinate. It comes in the shape of quickly dissolving pills. Giving the patient a more conventional manner to take their medication gave rise to the concept of fast-dissolving drug administration. The direct compression approach was used to manufacture fast-dissolving tablets containing doxylamine succinate. Evaluation criteria for the produced fast-dissolving tablets included weight variation, hardness, friability, disintegration time, drug content, wetting time, and short-term stability investigations. It was found that the % weight variation and drug content uniformity of all the formulations were within the approved range. Friability and hardness, two evaluation measures, demonstrated that every formulation's tablet had good mechanical resistance.