Online ISSN: 2515-8260

Issue 9,

Issue 9


Airway Assessment Of Traffic Policemen Using Spirometry Exposed To Environmental Air Pollution

Dr. Robin Singh Bhatti; Dr. Sachinkumar Dole

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 1-7

Background & Aims: Environmental air pollution including vehicular emissions remains a health hazard to those exposed including traffic policemen working in various metro and non-metro cities. The aim of this study is to evaluate the pulmonary functions of the traffic police officers posted at various traffic junctions throughout Pune city in order to ascertain whether prolonged exposure to environmental air pollution including vehicle exhausts have any adverse effects on the traffic police officers' lung functions.

CASE OF RETROPERITONEAL MASS WITH NEGATIVE BIOMEDICAL MARKER FOR PHEOCHROMOCYTOMA WITH ANTICIPATED DIFFICULT AIRWAY

Dr. Shilpa Deshmukh; Dr. Girish Saundattikar; Dr. Balkees Nazeer; Dr. Dheeraj Ravindran

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 8-12

ABSTRACT   Pheochromocytomas are catecholamine secreting tumours that arise from chromaffin cells of the sympathoadrenal system. They account for fewer than 0.1% of all cases of hypertension in adults but have lethal potential and are one of the few truly curable forms of hypertension. The symptoms with the greatest “pooled sensitivity” are hypertension, headache, palpitation, and diaphoresis. The diagnosis is based on these symptoms and high levels of plasma-free normetanephrine and/or metanephrine. This report is of the successful anaesthetic management of a 40-year-old female, a known case of hypertension for 10 years, with only low back ache, and vomiting as her presenting complaints, posted for excision of a retroperitoneal mass, whose intraoperative tumour manipulation led to a hypertensive crisis, showing its true colours! The histopathological report of resected specimen, obtained postoperatively, came to be consistent with pheochromocytoma. A high level of clinical suspicion of pheochromocytoma in such cases will turn out to be the saviour of the day, by prompting us to meticulously evaluate, appropriately optimise and adequately prepare for any intraoperative events in an otherwise “simple case abdominal mass excision!”

A Health Awareness and Govt. Schemes in India: A Study of Bihar State

Ashutosh Kumar Pandey; Dr. Amit Sharma; Amitabh Srivastava

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 13-20

The importance of health to society cannot be overstated. A key consideration for assessing social development is health. India and other developing nations face health problems. Numerous programmes have been established by the Indian Government to address public health issues. However, rural Indians are unaware about the health programme. The goal of the current study is to determine how informed people are of health-related initiatives. With the help of a closed-ended questionnaire, we conducted the survey. The findings show that opinion leaders are essential in helping the Indian government's health awareness efforts reach Bihar's rural residents. Although the audience's level of awareness is appropriate, more effort must be put into promotion.

“OVERVIEW OF IGEL VERSES UNCUFFED ETT IN PEDIATRIC POPULATION: A PROSPECTIVE, RANDOMIZED CONTROLLED TRIAL”

DR. SONAL KHATAVKAR; DR. DIPANJALI MAHANTA; DR. BALKEES NAZEER; DR. UJJWAL CHANDRA

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 21-30

Controlled ventilation with an endotracheal tube (ETT) has been considered gold standard. However, ETI is associated with hemodynamic instability during laryngoscopy and intubation and post operative complications which can be overcome by using IGEL. As there are only limited studies comparing its ventilatory efficacy to ETT, our comparative study evaluated adequacy of ventilation and clinical performance.

CARDIAC ARRHYTHMIA DETECTOR USING CNN APPLICATION

Dr. R. Kishore Kanna; U. Mutheeswaran; V. Subha Ramya; Dr. R. Vasuki; Dr. R Gomalavalli

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 31-38

In medical practise, an electrocardiogram (ECG) is a crucial indicator tool for assessing cardiovascular arrhythmias. In this study, a machine learning system is used to compare patient ECGs and perform programmed ECG arrhythmia identification. The system was previously tuned based on an overall image informational index. Arrhythmias are more prevalent in those over the age of 60. A convolutional neural network (particularly, Alex Net) is utilised to extract features, and the highlights are then passed via a basic back spread neural network to finish the classification. The fundamental purpose of this research is to provide a simple, effective, and relevant learning strategy for categorising the three types of heart conditions (cardiac defects) so that a diagnosis may be made. The findings showed that when a moving deep learning highlight extractor was combined with a standard back proliferation neural architecture, very elite rates could be achieved. In a comparative analysis, validation accuracy was shown to be 100 percent in Google Net, 94 percent in Squeeze Net, and about 97.33 percent in Alex Net.

HISTOLOGICAL DEVELOPMENT OF VASCULARITY AROUND HUMAN FOETAL SHOULDER JOINT

Dr. Sabia Nazir; Dr. Yasmeen Jan; Dr. Sunanda Raina; Dr. Sajad Hamid

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 39-47

Shoulder joint is a diarthrodial joint of ball and socket variety. Various components of shoulder joint start developing in early embryonic and foetal life at around 8 to 10 weeks. The present study aims to highlight the development of vascularity and cartilage canals around shoulder joint. Shoulder joint of 32 foetuses collected from areas in and around Jammu were dissected properly and decalcified in Gooding and Stewart’s solution. Sections were cut after obtaining blocks by paraffin wax embedding method. Slides were stained using Haematoxylin and Eosin and Masson’s trichrome and important findings were documented. Head of humerus is vascularised by cartilage canals by 10 weeks which arise from perichondrial vessels. In scapula, they develop around 12 weeks. Branching of cartilage canals is seen by 14 weeks. Synovial villi appear by 14 weeks and are vascularised by 16 weeks. Blood vessels enter joint in subcoracoid region. Epiphyseal vessels are seen to communicate with diaphyseal vessels at 17 weeks. Capillaries are seen in free margin of glenoid labrum by 12 to 12-1/2 weeks. Blood vessels are seen to develop in tendon of various muscles from 16 to 18 weeks.

A STUDY ON FINANCIAL ANALYSIS OF INDIAN TELECOMMUNICATION INDUSTRY: CASE STUDY OF RELIANCE JIO LTD.

Dr. Komal Gupta, Dr. Abhishek Tripathi .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 48-56

 India stands second-biggest broadcast communications market on the   planet. As about   January 2021, all out endorser base in the nation was at 1,183.49 million, while Gross income about   telecom area remained at Rs.185 billion in the second quarter about   2022. Since most recent 6-years there are parcel about   issues ,  issues looked by little organizations who were ruthlessly squashed by telecom pioneer. paper is  endeavor to concentrate on the   monetary execution about   significant telecom organizations about   India after section about   Dependence JIO. The company commonly referred to as Dependence Jio is Dependence Jio Infocomm Restricted. Plan about Action About Dependence Jio also recalls MTS, Milicom, TeliaSonera, Orange, English Telecom, Rogers, Tim, and Deutsche Telecom as directing current focus in the most effective way inductive methodology has been used to the telecom industry. Additionally, interpretivism thinking has been accepted, a test with a sample size of around 10 chiefs employed by Dependence Jio has been attempted, and crucial information has been obtained with the aid of a poll among managers employed by Dependence Jio.

A COMPRATIVE STUDY ON FINANCIAL PERFORMANCE OF SELECTED PUBLIC AND PRIVATE SECTOR BANKS OF INDIA

Ms. Muskan Diwan ,Ms. Neha Choithramani .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 57-65

This research is based on comparative financial analysis of selected Public and Private Sector Banks using ratios, The banks are selected based on top five & bottom five market capital of the Public and Private sector banks, Earning ratios(Net Interest Margin, Yield on Advances, Return on Equity, Return on Asset), Debt coverage ratios(cash deposit ratio, Investment deposit ratio, Debt to equity ratio, Loan to deposit ratio), Efficiency ratios(Net Non-performing Asset, Cost to income ratio, Operating cost to Asset ratio, Cost of liabilities), Growth ratios(Advances growth, EPS growth, Operating income growth), Liquidity ratios(Credit to deposit ratio, Current and Saving Account ratio, Interest expended to Total fund, Interest income to total fund),Balance sheet ratios(Capital adequacy ratio, Advance/loan fund)Leverage ratio(Current ratio and Quick ratio) Profit and Loss ratios(Interest expended to Interest earned, Other income to Total Income, Operating expenses to Total income) and etc.., this are some ratios which is used in this research, A Graphical representation is used to rank the performance of the bank and T-test is used to comparative analysis of the Public and Private sector banks Regression is used to find out the relation & Predictability of Liquidity(Current ratio, Cash to Deposit ratio, Credit to Deposit ratio, Investment to Deposit ratio) and profitability(Return on Equity, Net Interest Margin) of both Private and Public banks . The ratio data is taken One Year (2019), and this study is mainly focus on to find out the best sector in banking sector.

Age Estimation By Epiphyseal Union At Wrist Joint And Hand In Females

Arun M, Naveen N, Kagne RN .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 66-72

Age being one of the primary characteristics in establishing the identity of the individual, its estimation becomes an important task for the forensic expert especially in developing countries where birth records are not well maintained. In living it is not only important for identification but also for various civil and criminal purposes. Even the courts in India accept the ossification test as the reliable indicator of age as compared to physical and dental assessment of age.
This study comprised of 250 female subjects from Puducherry region, India. The age group of the subjects ranged from 14 to 19 years. Radiographs of the right wrist joint with hand of these subjects were taken and the epiphyseal union of the centres at the wrist joint and hand were noted.

Radiological Estimation Of Age By Epiphyseal Union At Wrist Joint And Hand Among Males

Arun M, Naveen N, Kagne RN .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 73-79

Age estimation plays a vital role in establishing the identity of the individual for the forensic expert especially in developing countries where birth records are not well maintained. In living it is not only important for identification but also for various civil and criminal purposes. Even the courts in India accept the ossification test as the reliable indicator of age as compared to physical and dental assessment of age.
This study comprised of 250 male subjects from Puducherry UT, India. The age group of the subjects ranged from 14 to 19 years. Radiographs of the right wrist joint with hand of these subjects were taken and the epiphyseal union of the centres at the wrist joint and hand were noted. The findings were compared with the recorded age given by various research workers.

Comparativeevaluationofnalbuphineandfentanylwithbupivacaine inlowerorthopedicsurgeries. “Randomized clinical trial”

Namita Gupta, Parekh Khushbu, Kiran Yadav, Sudhir Sachdeva, Avnish Bharadwaj .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 80-93

Background & Objective - This study aimed to compare efficacy of nalbuphine and fentanyl as adjuvant to bupivacaine in providing intra-operative anesthesia and post-operative analgesia in lower limb orthopedic surgeries, and to compare the characteristic of sensory and motor block, hemodynamic parameter, time of first rescue analgesia and adverse effects between two groups.
Method- In this clinical trial, 80 patients undergoing elective lower limb orthopedic surgeries under spinal anesthesia were randomly allocated in two groups. In group BN, the patients received 0.5% 3ml (Heavy Bupivacaine + 800 mcg Nalbuphine. In group BF patients received 0.5% 3ml (Heavy Bupivacaine + 25mcg Fentanyl.
Result & interpretation- The Onset of motor block, maximum level of block and time to reach peak level of block was significantly faster in group BF.While duration of motor block and time for first rescue analgesia was significantly prolonged in BN group. However, there was no significant difference in time for two segment regression=0.157 (NS) and hemodynamic changes.
Conclusion- We conclude that combination of fentanyl as adjuvant to bupivacaine provides higher segmental level sensory blockage, faster sensory and motor blockage than nalbuphine. But nalbuphine gives longer time of post-operative analgesia than fentanyl.

A Prospective Study Comparing Arthroscopic and Open Fixation in PCL Avulsion Injury

Dr. Sanjay Deo1, Dr. Shreyas B. Kappalguddi2 , Dr. Shivam Patel3, Dr. Abhishek Singh Bhadauriya4*, Dr. Bibin Selvin5 .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 94-106

INTRODUCTION - The posterior cruciate ligament (PCL) is a crucial component that helps keep the knee stable during flexion and rotation. Because the PCL is so robust, avulsion fractures at the PCL's attachment location are common. For complete restoration of PCL function, it is generally believed that avulsion fractures of the PCL should be anatomically reduced and fixed. Conservative therapies usually result in unsatisfactory outcomes, primarily due to functional disability and fracture non-union. Many surgeons think that the displaced or unstable tibial avulsion fracture of the PCL should be reduced and repaired anatomically using various techniques.

Comparative Activities Of Daptomycin, Linezolid, And Tigecycline Against Catheter-Associated Methicillin-Resistant Staphylococcus Bacteremic Isolates Embedded In Biofilm

Dr. C. Vijai Prasad, Dr. M. Abhul Sathar Sait, Dr. A. Ponnambalam .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 107-114

A vascular catheter may be saved if an intraluminal antibiotic lock treatment is used in the case of catheter-related bloodstream infections. These recently developed antibiotics were compared to the older antibiotics vancomycin and minocycline against methicillin-resistant Staphylococcus aureus (MRSA) embedded in biofilms in this in vitro study. We examined the emergence of MRSA after four hours of daily catheter lock therapy that was resistant to these antibiotics alone and with rifampin. Compared to linezolid, vancomycin, and the negative control, minocycline, daptomycin, and tigecycline are more effective at inhibiting MRSA in biofilms after the first day of exposure (P 0.001), with minocycline being the most active and daptomycin and tigecycline having weak activity, similar to the negative control. Among the antibiotics tested, daptomycin was the fastest in eliminating MRSA from biofilm after three days of exposure for 4-hour periods, followed by minocycline and tigecycline, which were faster than linezolid, rifampin, and vancomycin (P 0.001). After five days of exposure to MRSA continuously for four hours each day, rifampin alone was least effective at eradicating MRSA from biofilms because it promoted rifampin-resistant MRSA growth. It has been found that when rifampin is combined with additional antibiotics, the combination is far more effective at eliminating MRSA colonization than any single antibiotic alone. Daptomycin, minocycline, and tigecycline lock therapy also needs to be researched, as should the potential for rifampin's antistaphylococcal activity as a single agent, but not as a combined solution.

AMBROXOL AND BROMHEXINE INCREASE ANTIBIOTIC LEVELS IN THE LUNGS

Dr. C. Vijai Prasad, Dr. M. Abhul Sathar Sait, Dr. A. Ponnambalam .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 9, Pages 115-120

We have searched the literature for evidence of the pharmacokinetics (PK) effect of rifampin. Ambroxol co-administration was proven to be beneficial in the rat model, according to reports. A half-life increase in ambroxol levels in the lung tissue, leading to higher levels of rifampin in the lungs, [5] indicating a double increase in high concentration (Cmax) and an 80% increase in high concentration (Cmax) in mice. Any developments were evaluated in terms of their ability to develop literature. Drug-resistant and drug-resistant germs can be treated. Most pre-clinical trials use complete animals. Despite the fact that lung tissue levels are measured, most clinical studies rely on less invasive procedures such as sputum or bronchoalveolar lavage. In a pre-clinical study, Wiemeyer used mice given 50 mg / kg of oral ampicillin and amoxicillin. with or without oral ambroxol at a dose of 10 mg / kg, compared with the average human dose Ampicillin and amoxicillin tissue concentration increased by 23% and 27%, respectively, with combined ambroxol treatment. However, an increase in the level of antibiotics in the lung tissue is less likely to allow the treatment of antimicrobials, and many doses of antibiotics are already effective in the clinic, so improved effects of ambroxol combination therapy are also not possible. According to at least one clinical report of each class, bromhexine and ambroxol improve the levels of a variety of antimicrobial drugs in the lungs, including beta lactam, erythromycin, rifampin, and vancomycin. Aminoglycosides, fluoroquinolones, sulfonamides, and tetracyclines did not show the same increase, however it is unclear whether this is due to bias in the negative feedback reports or lack of research on these drugs.