Online ISSN: 2515-8260

Keywords : Antihypertensive drugs

A Review on Sustained Release Matrix Tablet of Antihypertensive Drug

Arvind Raghav, Ashish Singh Chauhan, Dharmendra Kumar, Km. Anjali, Pooja, Hareem Fatima, Mohd Ovaid, Supriya Maity

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 8473-8484

Now, the daily pharmaceutical industry is focused on developing common oral dosage forms as it becomes essential medical tool. This continuous-release formulation is designed to release the drug at a predetermined rate and keep the plasma drug overflow in a medical window with minimal side effects. The basic idea behind continuous drug delivery is to change the drug's biopharmaceutical, pharmacokinetic, and pharmacodynamics to reduce side effects, provide patient compliance, and treat the disease. Continued discontinuation of drug delivery improved patient compliance due to frequent drug administration, decreased flexibility in consistent drug levels, higher drug use, increased dosage of effective drug dosage, and reduced health care costs with improved treatment and shorter treatment duration. The main goal of the continuous-release forms is the development of drug treatment that has tested the relationship between the benefits and disadvantages of using a constant-release system. This review article contained basic information on the matrix type of the ongoing drug delivery system. Nowadays, there are very few drugs out of research and development, and existing drugs have a problem with resistance due to their unreasonable use, especially in the case of drugs such as antibiotics. Therefore, the mutation is an effective and efficient way to make a particular medication more effective with a slight change in drug delivery. Continuous extraction also provides a promising way to reduce the side effects of the drug by preventing fluctuations in the drug's therapeutic effect on the body. Drug administration through such a system involves controlled dispersal and distribution methods. If not correctly formulated, many medications can release the drug very quickly and may produce the drug's toxic effects orally. This article carries basic information about the structure of the release version and various similar types.


Ravi N Sangapur Anusha N Sangapur

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1514-1518

Background: Hypertension is a growing concern in the Indian population with urbanization and developments in work culture and treatment methods.
Aim and objective: To evaluate the influence of serum magnesium levels in gradations of primary hypertension and evaluate its impact on co-morbid conditions.
Methods: Hypertensive patients were screened and included in the study by categorizing them in to grade I and II based on blood pressure levels. Socio-demographic, physical and systemic examination details were recorded with pre-designed questionnaire; electrolyte levels, fasting blood sugar, status of retina and heart were assessed and analyzed using t-test and logistic regression.
Results:Total 100 patients in the study, mean age was 59.3±14.79 years; male predominance (61%); normal retina (83%) and presence of pre-diabetic conditions (67%) was observed, with normal serum magnesium levels in majority (76%). Serum magnesium levels were significantly associated with grade I (P = 0.0173) patients; influencing systolic and diastolic blood pressure values (r = -0.3552, P = 0.003; r = -0.2160, P = 0.0309, respectively).
Conclusion:The optimal values can be further established by evaluation of large sample size, quality of life during treatment, and influence of co-morbidities/complications of hypertension, among others.


Naga Latha Dhulipalla, Shashi Kiran Mishra, Varun Dasari, Veena Gadicherla, Perli Kranti Kumar

European Journal of Molecular & Clinical Medicine, 2018, Volume 5, Issue 1, Pages 476-491

Hypertension has been recognized as a common cardiovascular disease & a major risk factor
for congestive heart failure, ischemic heart disease, chronic renal failure & stroke. The aim of
the study is to observe the impact of clinical pharmacy activities on contemporary prescription
pattern of antihypertensive drugs and its compelling indications in atertiary care teaching
hospital.This prospective, study was conductedby reviewing and collecting the data of patients
who were diagnosed with Hypertension and admitted in the hospital. Patient demographic
details such as name, age, sex was collected.In present study we found 387 drug drug
interactions in prescriptions of 450 hypertension patients. However there is a need for improve
patient education on adherence to therapy and greater attention by clinicians to issues of life
style modifications, so as to improve BP control rate in this hospital.