Introduction: Hoarseness of voice is generally due to change in quality of voice. The etiology of hoarseness of voice varies from benign conditions to malignant disease, hence should not be ignored. The study's goal is to examine the demographic profile, etiopathological factors, and predisposing factors of hoarseness of voice Materials and Methods: This prospective case study was carried out in 100 patients presented in Department of ENT, Viswabharahti Medical College, Kurnool. patients of both sexes with hoarseness of voice for more than 2 weeks duration were included. All patients were subjected to detailed history, complete ENT examination, laryngoscopic examination, micro laryngeal excision or biopsy was taken to arrive at the diagnosis and management was done accordingly. Results: A majority of the patients were seen in the age group of 31 to 60 (78%) Hoarseness of voice is commonly seen in males, and male-to-female ratio is around 2.03:1. Smoking is found out to be the most common predisposing factor (40%) for the development of Hoarseness of voice. incidence being more common in laborers/farmers with 32%. The most common clinical presentation was Hoarseness of voice (100%), foreign body sensation 20%), neck swelling (20%) followed by dysphagia (13%), dyspnoea(15%) and vocal fatigue(15%). Out of the 100 cases in our study chronic specific laryngitis (32%) was found to be the most common cause of hoarseness of voice Conclusion: The symptom of hoarseness of voice should not be neglected because it may indicate laryngeal cancer. Any patient with hoarseness should be extensively checked to rule out laryngeal cancer, which can induce respiratory discomfort and life-threatening consequences.