Background: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. Type 2 diabetes (T2D) occurs due to a progressive decline in the ability of the pancreas to secrete enough insulin as well as insulin resistance in insulin target tissues. The pathophysiology of T2D is characterized by excessive accumulation of ectopic fat in the liver, pancreas, and skeletal muscles, eventually manifesting as insulin resistance in these tissues and pancreatic beta cell dysfunction that ultimately leads to hyperglycemia.Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistanceand obesity play key roles in the induction and progression of type 2 diabetesmellitus (T2DM). Objectives: To estimate the levels of serum myeloperoxidase, apolipoprotein B and glycated hemoglobin in type 2 diabetic patients and also in healthy controls, to observe the relationship between serum MPO with apo B and glycated hemoglobin and also between glycated haemoglobin with apo B in type 2 diabetic patients and healthy controls