Caffeine is known to stimulate the central nervous system and various studies have investigated the effects of caffeine on neurocognitive enhancement. Its benefits on exercise performance have not been fully elucidated by taking into consideration the various cardiovascular and respiratory parameters. The present study was done to analyse the effects of caffeine on cardiopulmonary efficiency using Harvard Step Test to calculate fatigue index, pre and post consumption of caffeine and compare the same by statistical analysis.25 healthy male and female MBBS Students whose caffeine intake is less than once in 2 weeks were selected for the study. Students who consume coffee/ any other caffeinated drink at least once a week were excluded. For finding out the cardiopulmonary efficiency of the students, Harvard step test was used and the fatigue index of each student was calculated before and after intake of 200 mg coffee. The results were compared with paired t test and p value was calculated. Majority of the students showed an increase in Fatigue Index after coffee consumption. Caffeine amplifies and promotes the sympathetic stimulation which occurs during physical exercise likely contributing to increased maintenance of performance and decreased fatigue index. So this interventional study showed that there is increased in cardiopulmonary efficiency post coffee consumption as increase in pulse post Caffeine Consumption was less as compared to pre caffeine.