Aim: Aim of the present study was to assess the efficacy of two local drug delivery systems in the treatment of chronic periodontitis. Materials and Methods: A total of 40 patients aged around 30–55 years were included in the present study.The enrolled patients underwent initial phase therapy which comprised scaling and root planning done by a single operator. Patients who fulfilled the selection criteria for the study were randomly allocated to two groups. Group 1: Tetracycline Fibers, Group 2: Chlorhexidine Gel. The plaque index (PI), the gingival index (GI), and periodontal pocket depth (PPD) were noted during baseline visit (before the local drug delivery), and these indices were rerecorded after 30 days after the local drug delivery. Results: The reduction of mean plaque index score was seen more in group 1 compared to group 2. There was no statistically significant difference found between the groups. The reduction of mean gingival index score and periodontal pocket depth was seen maximum in group 1 compared to group 2. There was a statistically significant difference found between the groups after the intervention. Conclusion: The present study concluded that, although thorough scaling and root planing are effective treatment methods for elimination of chronic periodontal pockets, improved results can be obtained by adjunctive use of locally administered tetracycline fibers and chlorhexidine gel.