Introduction: Present study was conducted to study clinical features, short term prognosis and etiological spectrum of optic neuritis (ON) in India. Materials and Methods: We enrolled fourty consecutive cases of ON. Clinical manifestation, blood and Cerebrospinal fluid studies, brain and spinal cord Magnetic Resonance Imaging(MRI) and Visual Evoked Potential(VEP) were done in all cases on inclusion in study. Intravenous methylprednisolone was given to all cases. They were all followed up upto six months. Outcome was assessed by Snellen’s chart. Results: Female gender was more affected than male (2.3:1). Mean age was 25.6±7.6 (16-55). Papillitis (80%) was more common than retrobulbar neuritis (20%). Bilateral presentation of ON was seen in 32% cases. Multiple sclerosis (MS) was diagnosed in 6(15%) cases, Neuromyelitis optica spectrum disorders (NMOSD) was diagnosed in 14 (35%) cases, Myelin oligodendrocyteglycoprotein antibody associated disorder was seen in 4(10%) cases, idiopathic optic neuritis was seen in 16(40%) cases. Conclusion: A variety of demyelinating and inflammatory disease cancauseON. NMOSD compared to MS is more common in India.