Introduction Proteinuria is a condition in which urine contains an excess amount of proteins . Examination of urine is one of the most rewarding tests in clinical biochemistry ,as not only does it uncovers renal diseases but also frequently points to a specific diagnosis . Normal daily protein excretion in an adult does not exceed 150 mg . Persistent proteinuria or microalbuminuria in any adult suggests not only the existence of renal disease but also an increased risk of MI and stroke . Aims and objectives To compare spot urine protein creatinine ratio with 24 hours urine protein as an index of quantitative proteinuria . Conclusions 1) Protein creatinine in the first morning urine sample is found to be a useful index for quantification of proteinuria in pts with varying degree of proteinuria and renal dysfunction 2) There was a goood positive correlation between spot urine protein creatinine ratio and 24 hours estimated protein . 3) The correlation was best in pts with normal or mildly impaired renal function with no nephrotic range proteinuria . 4) The positive correlation was least in patients with moderate to severe renal dysfunction . 5) Urine protein creatinine ratio is easy to perform , inexpensive and less time consuming . it can be used in outpatient setting for screening and quantification of proteinuria .