Online ISSN: 2515-8260

SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME 3-(4-SUBSTITUTED PHENYL)-2-PHENYL-4(3H)-QUINAZOLINONES

Main Article Content

Valarmathy Joshua, L. Samuel Joshua, Sherlyn Joshua, Vinolyn Joshua and W. D. Sam Solomon

Abstract

A new series of 3-(4-substituted phenyl)-2-phenyl-4-(3H)-quinazolinones 2(a-e) were synthesized by reacting 2-phenyl-4H-3-1-benzoxazin-4-one (1) with various primary amino compounds. The 2-phenyl-4H-3-1-benzoxazin-4-one (1) was prepared from anthranillic acid and benzoyl chloride. The structure of the title compounds was confirmed based on IR, 1H NMR, and Mass data. The compounds were screened for their antimicrobial activity and few of them were found to possess promising antimicrobial activity.

Article Details

Scimago Journal Rank