Introduction: Both clonidine and dexmedetomidine are alpha-2 adrenergic agonists that have analgesic as well as sedative properties and are being tried as newer adjuvants for analgesia. In addition to this, both have been shown to reduce the requirements of local anesthetics and enhance the analgesic effects without increasing the incidence of side effects.Thus, the present study was undertaken to compare postoperative analgesia according to VAS with dexmedetomidine and clonidine and assessment of Ramsay sedation score after complication of surgery with each drug