Background : Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteraemia in the first month of life .Incidence differs among hospitals depending on variety of factors . Blood culture is considered gold standard for the diagnosis, but does not give a rapid result. Hence , there is a need to look for a surrogate marker for diagnosing neonatal septicaemia . Material & Methods: 335 neonates were studied for clinically suspected septicaemia over a period of one year. Blood was cultured and organism identified biochemically. parameters of subject like EOS,LOS and Band cell counts were recorded . Result analysed statistically. Risks factors among Neonates were evaluated in terms of early and late onset sepsis. Results: Male preponderance was observed. Majority of the cases had a normal vaginal delivery. 47.46% cases had early onset septicaemia. Meconium stained liquor was the predominant risk factor. Culture postitvity was found to be 32. Conclusion: Band cell count can be used as one of the surrogate markers for neonatal septicaemia. An upsurge of Candida species as a causative agent in Neonatal septicaemia has been observed. And also other significant risk factor can be evaluated among Neonates, relatively in terms of early and late onset sepsis.