Background: The aim of the study is, to compare intermittent bolus versus continuous infusion of cisatracurium in neurosurgical procedures. Materials and Methods: A prospective, randomized, single blind control study was conducted on 32 adult patients undergoing craniotomy under general anesthesia at King George Hospital, Visakhapatnam during the period from August 2019-August 2021, after obtaining the approval from Institutional Ethical Committee (Andhra Medical College) and written informed consent from the patients who participated in this study. In this study 32 adult patients aged between 18 – 65 years, belonging to ASA grade I and II, undergoing craniotomy under general anesthesia were randomly assigned into two equal Intermittent Bolus and Continuous Infusion groups, to assess the intraoperative hemodynamics, cost effectiveness, muscle relaxation and postoperative recovery characteristics of the two technique of administering muscle relaxants during intraoperative period