Machine learning is the most efficient technology and played a major role in the industry domain. It has various applications and espe- cially in healthcare domain machine learning has improved a lot as it has been used for discovering various patterns form diverse sources to pro- vide efficient methods for the prediction of disease. This paper describes various algorithm of machine learning which deals with the development of an effective and efficient decision support system pertaining to ap- plications related to healthcare. This paper has overcome the research gap for the development of an effective decision support system for the application of healthcare