Background: Fever is a common problem in medicine since it is the occult presentation of common diseases rather than actual disorders. Although infection is the most prevalent cause of thrombocytopenia, thrombocytopenia accompanied by fever aids in the differential diagnosis and management of fever. The present study aimed to evaluate the clinical and laboratory profile of cases of fever with thrombocytopenia. Methods: Based on the inclusion and exclusion criteria a total of n=160 cases were included in the study. A detailed history was obtained regarding the duration of fever, and history of travel. Symptoms of headache, nausea, vomiting, abdominal pain, diarrhea, cough, anorexia, myalgia, gum bleeding, oliguria, hematuria, and weight loss were noted. Rashes, dehydration signs, petechiae, jaundice, lymphadenopathy, hepatomegaly, splenomegaly, anemia, abdominal pain, altered sensorium, and other symptoms were noted