Inflammatory bowel diseases (IBD) are subdivided into ulcerative colitis (UC) and Crohn’s disease (CD). Several lines of evidence suggest that CD and UC are different diseases. However, some patients (10–12%) cannot be easily classified into either and a final diagnosis of indeterminate colitis is made. Making an earlier, more accurate diagnosis of IBD is important as the management of CD and UC is different, especially when surgery is planned. A search for serological tests to differentiate CD from UC has been underway for a long time. An ideal serological marker should have high sensitivity, high specificity, and high predictive values. In this study we want to assess the usefulness of serological markers as a diagnostic test and correlation with other parameters in the natural history of ulcerative colitis and there are already lots of studies available regarding this in western literature but lacking in south India especially using panel of markers.