Nature is the biggest source of medicines, whole over the world. A number of materials from plants, animals and minerals have been identified and used successfully for the treatment of various human ailments. CommiphoraMukul is a significant antiquated restorative plant of the Burseraceae family. Gum guggul (oleo-gum-resin) is obtained by making cut in bark of Commiphoramukul having a place with the family Burseraceae and is found widely in the dry districts of the Indian subcontinent. Guggul contain flavonoids, phytosterols and terpenes which are responsible for number of biological activities like anti-inflammatory, antiobesity, antineoplastic and antidiabetic. This review is mainly to update information regarding its pharmacological benefits of CommiphoraMukul.