Background: Nicotine is a remarkable product when considering the number of disease to which it can reliably be linked as a casual aspect or as a factor which is partially responsible for the occurrence of disease. Nicotine dependence is not only a risk factor but is also related with low health related quality of life and high psychiatric co-morbidity Objectives: The objective of this study to assess the knowledge scores about Nicotine dependence among adolescents residing in selected area Methods: In present study, researcher adopted A Non probability convenient sampling technique was used. Semi structured questionnaire and planned health teaching on knowledge about nicotine dependence. Data collection done on 60 samples. Association was done by Fisher’s exact test with selected demographic variable. Result: A qualification variation in the sample, there has been no significant difference between their knowledge scores. There was positive co-relation between the age and the pre-test knowledge scores of the samples. Older the adolescent, higher was the pre-test knowledge scores. Conclusion: Findings of the study revealed that after receiving planned teaching the posttest scores increased, this shows that the planned health teaching was very effective as the adolescents are very receptive towards the planned teaching on nicotine dependence.