Background: Sinusitis refers to a group of disorders characterized by inflammation of the mucosa of the paranasal sinuses. The present study was conducted to assess efficacy of middle meatal antrostomy in the management of chronic maxillary sinusitis. Materials & Methods:62 patients of chronic maxillary sinusitis of both gendersunderwent complete otorhinolaryngological examination with nasal endoscopy under local anesthesia. A clinical otorhinolaryngological examination and nasal endoscopy was repeated on visits 2 weeks, 3 months, 6 months and 1 year postoperatively. Results: Radiological score 0 was seen in 10, 1 in 20 and 2 in 32. Endoscopic appearance score for polyp at baseline was 26, at 6 months was 10 and at 1 year was 1, endoscopic appearance score for odema at baseline was 54, at 6 months was 12 and at 1 year was 2. Endoscopic appearance score for secretion at baseline was 62, at 6 months was 20 and at 1 year was 4. Symptoms score at 6 months for nasal blockage was 26, facial pain was 11, headache was 5, epistaxis was 6, post nasal discharge was 7. Symptoms score at 1 year for nasal blockage, facial pain, headache, epistaxis and post nasal discharge was 5, 2, 1, 1 and 2 respectively. The difference was significant (P< 0.05). Conclusion: Middle meatal antrostomy is a safe and effective procedure in patients suffering from chronic maxillary sinusitis.