Introduction: Vesicles and bullae are associated with various conditions in paediatric practice. These conditions may be Inherited, Drug Related, Infectious, Autoimmune and Miscellaneous. While Epidermolysis Bullosa (EB) is a type of Inherited Bullous disorder, Steven Johnson’s Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are drug reactions characterized by epidermal detachment and necrolysis presenting with macules, papules, plaques and flaccid bullae. Being rare in paediatric practice and of acute onset, they pose both diagnostic and management challenges. Our three patients had an Acute presentation with Blistering skin lesions at the onset.