The aim of the present study was to establish the Tweed’s parameters for South Indian population. A study of 70 South Indian young adults (35 males and 35 females) within age range of 18-28 years with acceptable profile and occlusion were selected for the study and assessed using Tweed’s analysis. The three angular parameters of Tweed’s analysis, Frankfort Mandibular plane angle (FMA), Frankfort Mandibular Incisal Angle (FMIA) and Incisor Mandibular plane angle (IMPA) for the South Indian population was measured and found to be 23.1, 57.1 and 99.8 degree respectively. Significant difference was seen among young adult South Indian population and Caucasian values of Tweeds diagnostic triangle. There was a difference in between the mean values of FMA and FMIA among male and female South Indian population and the IMPA did not show any difference.