Scrub typhus is one among the common causes of Acute Undifferentiated Febrile Illness(AUFI) in Asia especially from India. Objective - The present study aims to describe the clinical features, lab diagnosis, complications and outcome in scrub typhus from Southern Rajasthan, India. Method -This present prospective, observational, hospital-based study was conducted in the Department of Microbiology of AIMS &RC, Rajsamand, located in Southern Rajasthan, from January 2021 to Dec 2021.Scrub typhus was diagnosed in the microbiology laboratory by carrying out SD Bioline, one step scrub typhus for detection of IgM antibody. Result -A total of 500 patients suspected of AUFI were included in study. Out of which 88 patients were diagnosed to have scrub typhus by rapid card method detecting IgM antibody. Fever (100%) was the most common symptom and the duration of illness at the time of detection was less than 1 week in 70% cases. The most predominant sign noted in our study was icterus in 41% cases followed by hepatosplenomegaly. Elevated transaminase level was detected in 75% cases followed by increased serum urea/creatinine level and thrombocytopenia in 50% and 39% cases respectively. Acute hepatitis was found in majority of patients ie in 75% cases followed by acute kidney injury in 49% cases. The overall mortality rate was 16%.