Aim: comparative assessment of efficacy of topical amorolfine, luliconazole, sertaconazole, terbinafine in tinea corporis and tinea cruris. Material and methods: This was a prospective, randomized study was done in the Department of skin and VD, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India for one year Total 100 divided into four groups with 25 patients in each category of antifungal were considered. Consecutive eligible patients were prescribed topical amorolfine (0.25%), luliconazole (1%), sertaconazole (2%) and terbinafine (1%) in a serial order. We evaluated the improvement in the pruritus, erythema and scaling with score 0 for no improvement, score 1 for partial improvement and score 2 for complete improvement. Therapeutic response was statistically evaluated using Kruskal Wallis test and Fishers exact test. Results: Among 100 patients 44 were treatment naive, 25 were topical steroid (with or without antifungal) modified cases, 23 were partially treated with antifungals and 8 had used home remedies prior to the study. Luliconazole showed best improvement of pruritus (mean1.53), erythema (mean-1.48) and scaling (mean- 1.47). Terbinafine showed the least improvement with mean being 0.62, 0.52, 0.77 for pruritis, erythema and scaling respectively. Difference in the mean values of improvement of luliconazole as compared to the other three drugs was significant for pruritus (P=0.019) and highly significant for erythema and scaling (P=0.003&0.006). A total of 16 patients (64%) in luliconazole group showed good response as compared to the other drugs. These differences in the improvement of patients was statistically significant as compared to other drugs (P= 0.014). Conclusion: We concluded that the Luliconazole is better as compared to other antifungal.