The aim of the study was to compare clinically and radiographically the pulpotomies are done using form cresol (FC), calcium hydroxide (CH), and mineral trioxide aggregate (MTA). Nineteen children in the age group of 3 – 6 years with a total of 39 teeth requiring pulpotomy were selected. Thirty-nine teeth were divided into 13 in each group and randomly treated with 1 of the 3 pulpotomy agents. The children were called for a follow-up at 3, 6, and 9 months. The follow-up evaluation resulted in 92.31% success for FC, 61.53% for CH and 100% success for MTA at the end of 9 months. Statistics revealed no significance in the success rate between formocresol and MTA while the difference in the success rate between calcium hydroxide and MTA was statistically significant. Discoloration of the crown was observed in teeth treated with MTA though there were no clinical and radiographic signs and symptoms