AIM-This study aimed to compare the effectiveness of Kinesio taping fascial techniques with myofascial release and conventional treatment in patients diagnosed with knee osteoarthritis (OA) presenting iliotibial (IT) band tightness. METHODOLOGY- A total of 45 participants with knee OA and IT band tightness were randomly assigned to one of three groups: Kinesio taping fascial, myofascial release, or conventional treatment. Outcome measures included pain intensity, functional status, and IT band tightness assessed at baseline, post-treatment, and follow-up visits. RESULT- Revealed that all three interventions led to significant improvements in pain, functional status, and IT band tightness compared to baseline within each group. However, the Kinesio taping fascial group demonstrated superior outcomes in pain reduction and functional improvement compared to the myofascial release and conventional treatment groups. Furthermore, the Kinesio taping fascial group exhibited sustained improvements at follow-up compared to the other groups. CONCLUSION: These findings suggest that Kinesio taping fascial techniques may be more effective than myofascial release and conventional treatment in managing knee OA with associated IT band tightness