Introduction: Handgrip muscle strength is the maximum force developed during maximal voluntary contraction under given set of conditions. Nerve and muscle functions are closely related to human motor performance.Hand grip strength means muscular strength and force that the person can generate with their hands which can be quantified by measuring the amount of static force that a person’s hand can squeeze around a dynamometer. Aims and Objectives:To measure and compare handgrip strength in sedentary group and those of physically exercised group Materials and Methods:Present was conducted in 150 healthy medical students of DVVPF’s medical college. (75 sedentary group,75 physically exerciser group) Using questionnaire items on physical exercise we divided them into two groups depending on metabolic equivalent task (MET) Sedentary Group/Non-Exercised Group- not doing any kind of physical exercise in the last 1 year or amount metabolic equivalent (METS) is less than 600 MET-min/week. Physically Exerciser Group – doing physical exercise for the period of 1 year in the form of aerobic exercise, bicycle riding, swimming Gym, etc. for 40 -45 minutes, 5 day/week or MET is more than 600 MET-min/week.Maximal handgrip strength of dominant hand was measured by handgrip dynamometer twice at an interval of 1 minute, and higher reading recorded was considered to be the maximum hand grip strength for each student data was analyzed by unpaired t test using SPSS. we found handgrip strength in physically exerciser student’s group (46.50+- 5.0) was statistically significant (p<0.001) as compared to sedentary /non exerciser student’s group (40.30+-4.50).