Aim: The aim of the present study was to find a correlation between histopathological, radiological findings, and immunohistochemical findings in neoplastic breast lesions. Methods: This study was a prospective study conducted at the Department of Pathology, Government Medical College and Rajindra Hospital Patiala, Punjab. A total of 70 cases of neoplastic breast lesions over a period of 2 years, which had BIRADS score reports, received in the pathology department as trucut biopsies, lumpectomy, and mastectomy specimens were examined histopathologically and immunohistochemistry (ER, PR, HER-2/neu) was done. Results: In the present study, the age ranges from 14 to 80 years. Out of 70 patients with breast lumps, the highest percentage (42.9%) was seen in females aged 21 to 40 years (30 out of 70). Mean+ S.D age was 37.06 + 17.04. The median age was 35 years. The most common BIRADS category was category 3 with 30 out of 70 cases (42.9%) followed by category 4 with 21 out of 70 cases (30%). 10 cases (14.3%) were seen in category 5. In 70 breast lump cases studied, a broad spectrum of histopathological neoplastic breast lesions like benign, borderline, and malignant were identified. In benign breast lesions, the most common was a fibroadenoma, which was present in 48.6% of the cases. Among malignant breast lesions, the most common was an invasive ductal carcinoma which was present in 30% of the cases. 4 cases with borderline histopathology were also identified. A comparison of all the parameters showed a high diagnostic accuracy of 87.14%, a sensitivity of 89.66%, and a specificity of 85.37% in BIRADS and histopathology. Immunohistochemistry revealed 77.14% ER/PR positive and HER2 negative cases, 17.14% HER2/neu positive, 5.7% triple-negative, and 5.7% triple-positive tumors. Conclusion: The present study concludes that, there is a statistical correlation between radiological (BIRADS), histopathological diagnosis, and immunohistochemistry findings in neoplastic breast lesions. All these techniques have high sensitivity, specificity, and accuracy in making the final diagnosis.