Background:Organophosphate (OP) poisoning is an important cause of poisoning all over the world. Prompt recognition and aggressive management of acute intoxication are essential to minimize the morbidity and mortality from these potentially lethal compounds. Present study was aimed to study correlation of serum amylase with outcome in acute organophosphorous poisoning at a tertiary hospital. Material and Methods: Present study was hospital based, prospective, observational study, conducted in patients of OP poisoning, >18 years age, confirmed by history, circumstantial evidence of poisoning, specific clinical examination, and basic laboratory reports