Background: Direct laryngoscopy followed by endotracheal intubation is prone to haemodynamic fluctuations which may be detrimental in subjects with coronary artery disease, hypertension, and cerebral vascular disease. The aim is we wanted to compare Dexmedetomidine with Magnesium sulphate to determine the better drug with regard to attenuation of the haemodynamic responses during laryngoscopy and endotracheal intubation.