Background: Conventional vitiligo treatment on the hands and feet frequently yields disappointing results. In the face, neck, and truncal areas, various ablative therapy approaches were tested with positive results. Material and methods: On 44 individual patients in each group with 44 pair-lesions of non-segmental vitiligo on both hands, a prospective randomized study was done. In (Group A) treatment with fractional CO2 laser, NB-UVB phototherapy, and 0.05 % clobetasol propionate cream and NB-UVB phototherapy and 0.05 % clobetasol propionate cream was given (Group B). For ten sessions, fractional CO2 laser was used at four week intervals. NBUVB phototherapy was given twice a week for a total of 20 sessions. Twelve weeks following the last therapy, the patients were assessed. Standard digital pictures, patient satisfaction, and adverse events were used to assess the outcomes.