The aim of the study was to study the characteristics of the main clinical and diagnostic indicators of cerebral venous circulation in patients with hypertensive encephalopathy of various stages and their dynamics against the background of drug therapy using cytoflavin. To this end, we analyzed the clinical and instrumental data of the examination of 105 patients at the neurological department of the clinic of the Tashkent Medical Academy with an established diagnosis of hypertensive encephalopathy of various stages. Cerebral hemodynamics was investigated using the transcranial duplex scanning of the veins and sinuses of the brain. In 85 patients who had diagnostic signs of cerebral venous dysfunction, two groups were formed depending on the treatment regimen: standard antihypertensive therapy using Cytoflavin: 2 tablets 2 times a day from 1 to 30 days inclusive (main group - 39 people) - and without it (control group - 46 people). Control studies of cerebral hemodynamics were performed in both groups on the 30th and 60th day from the start of therapy. The patients who received cytoflavin in the treatment regimen showed a slight improvement on the 30th day and a significant improvement in venous cerebral circulation indicators on the 60th day (p <0.05), which made it possible to conclude that the drug is effective for improving cerebral venous hemodynamics, and allows recommend it in the complex therapy of patients with hypertensive encephalopathy of various stages with existing venous cerebral dysgemia.