Submit your articles to the African Journal of Biomedical Research, active in Scopus Q3 and Clarivate Web of Science Zoological Records. Click here to submit your manuscript.
Volume 11 (2024) | Issue 5
Volume 11 (2024) | Issue 5
Volume 11 (2024) | Issue 5
Volume 11 (2024) | Issue 5
Volume 11 (2024) | Issue 5
Abstract. The presence of cardiovascular autonomic neuropathy (CAN) significantly worsens the prognosis and course of the underlying disease. So in patients with diabetes mellitus (DM) and CAN, the mortality rate for 5 years is five times higher compared to patients without this complication. Due to the fact that CAN is closely associated with cardiovascular pathology, many authors consider CAN as a significant factor in cardiovascular risk. Purpose. To establish clinical, functional and metabolic changes in diabetic autonomic cardiovascular neuropathy in children with type 1 diabetes. Materials and methods research. The total number of patients studied by us was 114 children with type 1 diabetes mellitus aged 4 to 18 years. We conducted laboratory and instrumental research methods. Laboratory methods: general clinical research (general analysis of blood and urine, studies of blood sugar), biochemical methods (total blood protein, bilirubin, cholesterol, triglycerides, creatinine, urea, electrolytes, glycated hemoglobin), 24-hour heart rate monitoring with circadian index estimation was used and parameters of time and frequency analysis of heart rate variability. Conclusion diabetic autonomic cardiovascular neuropathy in children with type 1 diabetes is characterized by the development of tachyarrhythmic rhythm disturbances, as well as the formation of rigidity of the heart rhythm and a decrease in the sensitivity of the sinus node to parasympathetic influences according to a temporary analysis of daily monitoring of heart rhythm.