Abstract:Immunobiology is the branch of science that deals with immunological effects which includes phenomenan like infectious diseases, growth and development, hypersensitivity, heredity, aging and transplantation. In this review article, we have compiled the immunobiology of the nCoV, which has led to the world wide panic causing a major pandemic. Coronavirus (CoV) is a large family of viruses that has led to mild to severe illness, with magnified cytokine storms in the lungs. The severe forms of these viruses involve Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A new strain of virus that had not been earlier detected in humans is the Novel coronavirus (nCoV). The major structural protein, the spike protein S seems to be the highly potent moiety involved with viral fusion and entry into the host cells through ACE receptors. This review thus throws insights into the immuno-biology of the spike protein and its role in the immuno-pathogenesis of CoV.